Numerous data from the use in pregnant women (more than 1000 reported cases) indicate a lack of ability to cause fetotoxicity and developmental defects in the fetus. Metoclopramide can be used during pregnancy (I-II trimesters) only if the potential benefit to the mother outweighs the potential risk to the fetus. Due to the pharmacological characteristics (like other neuroleptics). when using metoclopramide in late pregnancy can not exclude the likelihood of extrapyramidal symptoms in the newborn. Metoclopramide proviron for sale should not be used in late pregnancy (during the III trimester). In the application of metoclopramide should monitor the condition of the newborn. Breastfeeding Period metoclopramide in a small amount is excreted in breast milk. We can not exclude the possibility of adverse reactions in children. The use of metoclopramide in the breastfeeding period is not recommended. If necessary, use during lactation should stop breastfeeding.
Dosing and Administration
Inside. Adults and children over 15 years weighing 60 kg recommended dose of 1 tablet (10 mg) to three times a day. The maximum recommended daily dose of 30 mg or 0.5 mg / kg body weight. Children start 15 years with a body weight less than 60 kg recommended dose is 1.2 tablets (5 mg), 1-3 times a day. The maximum recommended daily dose of 0.5 mg / kg / day. in order to prevent overdosing is necessary to observe the minimum interval between doses 6 h, even in the case of vomiting. The maximum duration of treatment is 5 days. elderly patients elderly patients may require a dose reduction, depending on the performance of the kidneys and liver, and general condition. renal insufficiency proviron for salein patients with end-stage renal failure (creatinine clearance less than 15 ml / min) daily dose should be reduced by 75%. In patients with renal insufficiency, moderate, or severe severity , the dose should be reduced by 50%. Abnormal liver function in patients with hepatic insufficiency, severe gravity of the dose should be reduced by 50%.
The frequency of side effects is classified as follows: very common frequency not known (can not be estimated on the basis of available data). from the blood and lymphatic system: the frequency is unknown – methemoglobinemia, probably due to a deficiency of the enzyme NADH-dependent cytochrome-b5 reductase. especially in newborns, sulfgemoglobinemiya (most often, while the use of high doses of sulfa drugs), leukopenia, neutropenia, agranulocytosis. From the heart:infrequent bradycardia: frequency unknown cardiac arrest, which may be caused by bradycardia, atrioventricular block, sinus block, prolongation of the interval in the electrocardiogram, arrhythmia type “pirouette”. on the part of the vessels: often – lowering blood pressure; the frequency is unknown – cardiogenic shock, acute increase in blood pressure in patients with pheochromocytoma. On the part of the endocrine : infrequently – amenorrhea, giperirolaktinemiya: rarely – galactorrhea; . frequency proviron for sale is unknown – Endocrine disorders during long-term treatment are associated with hyperprolactinemia (amenorrhea, galactorrhea, gynecomastia).