proviron dosage

After intake of rapidly absorbed, time to maximum plasma concentration of 30-120 minutes. Bioavailability is 60-80%.
It is metabolized in the liver. The half-life is between 3 to 5 hours in renal impairment may be increased to 14 hours. Excreted by the kidneys within naposim proviron dosage 24 hours as unchanged or as metabolites (about 80% of the dose). Easily penetrates the blood-brain barrier and is excreted in breast milk.

Indications

 

  • Prevention of postoperative nausea and vomiting.
  • Symptomatic treatment of nausea and vomiting, including in acute migraine.
  • Prevention of nausea proviron dosage and vomiting caused by chemotherapy and radiotherapy.

Contraindications

 

  • Hypersensitivity to metoclopramide and the components of the drug;
  • gastrointestinal bleeding, mechanical intestinal obstruction or perforation wall of the stomach and intestine, a condition in which stimulation of peristalsis of the gastrointestinal tract is a risk;
  • confirmed or suspected pheochromocytoma due to the risk of severe arterial giperteizii;
  • tardive dyskinesia, which developed after treatment with neuroleptics or metoclopramide in history;
  • epilepsy (increasing frequency and severity of seizures);
  • Parkinson’s disease;
  • simultaneous application of L-dopa and dopamine receptor agonists;
  • methemoglobinemia due to receiving metoclopramide or deficiency of nicotinamide adenine dinucleotide proviron dosage of cytochrome-b5 in history;
  • prolaktinoma prolaktiizavisimaya or swelling;
  • lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
  • Children up to age 15 years;
  • during breastfeeding.

Carefully

When applied in the elderly; in patients with impaired cardiac conduction (including the lengthening  interval), a violation of water-electrolyte balance, bradycardia. taking other drugs prolonging  interval, arterial hypertension; in patients with concomitant neurological disorders, depression (history); in renal failure secondary to severe (creatinine clearance 15-60 ml / min); proviron dosage with severe hepatic insufficiency severity; pregnancy.