proviron cycle

After intake of rapidly absorbed. The maximum plasma concentration  reached after 1 hour. The drug with food does not affect the absorption, but the absorption rate is somewhat reduced . The distribution. Cetirizine binds to plasma proteins 93% . The volume of distribution. Provided with breast milk. Not accumulates. Metabolism. In small quantities, is metabolised to a pharmacologically inactive metabolite (unlike other blockers of H1-histamine receptors, metabolized in the liver with the participation isozymes of the cytochrome P450 system). Withdrawal. 60% of the drug is excreted unchanged by the kidneys within 96 hours and about 10% is released through the intestines. The half-life proviron cycle is 7-10 hours practically not removed by hemodialysis.. Pharmacokinetics in special clinical situations.  Children aged 6-12 years – 6 hours in patients with impaired renal or hepatic function slows excretion of the drug. and increased .

 

Indications for use : Adults and children over 12 years

 

  • Symptomatic treatment of seasonal and perennial allergic rhinitis with concomitant allergic conjunctivitis;
  • chronic idiopathic urticaria. Children aged 6 to 12 years
  • Symptomatic treatment of seasonal and perennial allergic rhinitis;
  • chronic idiopathic urticaria.Contraindications
    : Hypersensitivity to cetirizine, to other components of the drug and a piperazine derivative; Children under 6 years of age; pregnancy; breastfeeding; end-stage renal failure; patients on hemodialysis; lactose intolerance, lactase deficiency; glucose-galactose malabsorption syndrome.Precautions
    Chronic renal failure secondary to severe; age over 65 years; simultaneous application of drugs, have a depressing effect on the central nervous system proviron cycle, such as barbiturates, opioids, ethanol, benzodiazepines, zolpidem, and others.

    Use during pregnancy and breast-feeding
    Cetirizine is contraindicated in pregnant women, as insufficient data on safety and efficacy.
    There is no data on the allocation of cetirizine in breast milk, cetirizine should not be used during breastfeeding.

    Dosing and Administration

    After intake of rapidly absorbed. The maximum plasma concentration (proviron cycle reached after 1 hour. The drug with food does not affect the absorption, but the absorption rate is somewhat reduced (time to reach C max is increased by 1 hour). The distribution. Cetirizine binds to plasma proteins 93% . The volume of distribution (Vd) – 0,5 l / kg. Provided with breast milk. Not accumulates. Metabolism. In small quantities, is metabolised to a pharmacologically inactive metabolite . Withdrawal. 60% of the drug is excreted unchanged by the kidneys within 96 hours and about 10% is released through the intestines. The is 7-10 hours practically not removed by hemodialysis.. Pharmacokinetics in special clinical situations. T1 / 2 children aged 6-12 years – 6 hours in patients with impaired renal or hepatic function slows excretion of the drug. and increased T1 / 2.